Nuclear localization of active HGF receptor Met in aggressive MDA-MB231 breast carcinoma cells
نویسندگان
چکیده
منابع مشابه
Nuclear localization of active HGF receptor Met in aggressive MDA-MB231 breast carcinoma cells.
Hepatocyte growth factor (HGF)/Met system is deregulated in tumors and is implicated in different aspects of invasive growth. Here, we report that in the highly aggressive MDA-MB231 breast carcinoma cells, Met cytosolic fragments [C-terminal fragment (CTF)] were present in the nuclei. They were constitutively active because tyrosine phosphorylated at regulatory and catalytic domains and endowed...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2009
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/bgp080